漸凍人(ALS)治療總整理Part-VII最終回Part-II(建議善存+500毫克維他命C+高劑量維生素E)
告訴我們:
漸凍人(ALS)治療總整理Part-VI最終回(缺鎂鋅錳維它命B12,建議善存+豆漿+茶。)
告訴我們:
六核苷酸Hexanucleotide (GGGGCC)在C9orf72的非編碼區中的重複擴增是全球範圍內家族性ALS和額顳癡呆(FTD)的主要原因。
在ALS患者的CSF或血清中未檢測到IFN-γ,TNF-α,IL-2,IL-4,IL-5和IL-10
降低的C9ORF72水平會導致自噬不足,從而損害DPR蛋白的清除並導致其毒性積累,
最終導致神經元細胞死亡
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Reduced hnRNPA3 increases C9orf72 repeat RNA levels and dipeptide-repeat protein deposition.
減少的 hnRNPA3 增加了 C9orf72 重複 RNA 水平和二肽重複蛋白沉積。
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Small interference RNA sequence against HNRNPA3 (shA3)
針對 HNRNPA3 的小干擾 RNA 序列(shA3)
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Artificial MicroRNAs Targeting C9orf72 Can Reduce Accumulation of Intra-nuclear Transcripts in ALS and FTD Patients
靶向 C9orf72 的人工微 RNA 可以減少 ALS 和 FTD 患者核內轉錄本的積累
Recently, however, the expression of some of these myomiRs (miR-1, miR-23a,miR-26a, miR-27b, miR-29b, miR-133a, miR-206, and miR-455) has been re-examined by using qPCR methods
in muscle samples of ALS patients and controls51, and miR-1, miR-26a, miR-133a, and miR-455 were shown to be signifcantly decreased in patients.
在 ALS 患者和對照的肌肉樣本中,miR-1、miR-26a、miR-133a 和 miR-455 在患者中顯著降低。
IL-10 stimulation resulted in the inhibition of miR-147 expression induced in response to LPS, while having a potentiating effect on the induction of miR-455.
IL-10 刺激導致對 LPS 響應誘導的 miR-147 表達的抑制,同時對 miR-455 的誘導具有增強作用。
IL-19 driven miR133a expression links lipid metabolism and anti-inflammation.
IL-19 驅動的 miR133a 表達將脂質代謝和抗炎聯繫起來。
IL19 and IL20 were cloned through a search for genes ho- mologous to the IL10 gene (Blumberg et al., 2001; Gallagher et al.,. 2000)
通過搜索與 IL-10 基因同源的基因克隆 IL-19 和 IL-20(Blumberg 等,2001;Gallagher 等,2000)
IL-4 enhances IL-10 production in Th1 cells
IL-4 增強 Th1 細胞中 IL-10 的產生
miR-26a Immunological component/process:Chemokine ligand (CCL) 22, IL10 and macrophage infiltration
miR-26a 免疫成分/過程:趨化因子配體 (CCL) 22、IL-10 和巨噬細胞浸潤
Several of these IFN-induced miRNAs (miR-1, miR-30, miR-128, miR-196)
幾種干擾素誘導的 miRNA(miR-1、miR-30、miR-128、miR-196)